- Arrythmias are a group of conditions in which there is an alteration in the rate or rhythm of the heart. The heart can beat too fast, too slow or with an irregular rhythm. Arrythmias are caused by changes in heart tissue and activity or in the electrical signals that control your heartbeat. These changes can be caused by damage from disease, injury or genetics including cardiac channelopathies. Cardiac channelopathies are a group of inherited conditions that are associated with a defect in the cardiac ion channel function. These problems cause an increased susceptibility to abnormal heart rhythm (dysrhythmia or arrythmia), most often ventricular tachycardia or ventricular fibrillation that ultimately can lead to sudden cardiac death (SCD). The differential diagnosis between ion channel disease and cardiomyopathies can be challenging on occasion as severe ventricular dysrhythmias can manifest in patients with cardiopathies or with structurally normal hearts.
- The Igenomix Arrythmia Precision Panel serves as a diagnostic and screening tool ultimately leading to a better management and prognosis of the disease. It provides a comprehensive analysis of the genes involved in this disease using next-generation sequencing (NGS) to fully understand the spectrum of relevant genes.
- The Igenomix Arrythmia Precision Panel is indicated in those cases where there is a clinical suspicion of arrythmia with the following manifestations:
- Shortness of breath
- Fainting or nearly fainting
- Fluttering of the chest
- Chest pain
- Sudden weakness
- Blurry vision
The clinical utility of this panel is:
- The genetic and molecular diagnosis for an accurate clinical diagnosis.
- Early initiation of treatment with a multidisciplinary team for appropriate preventive ICD placement, pacemaker, pharmacologic therapy, or interventional procedures.
- Prevent complications including stroke, heart failure or sudden cardiac death.
- Risk assessment and genetic counselling of asymptomatic family members according to the mode of inheritance.
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